Currently, there are a wide range of approaches to deploying digital ads, with advanced technologies now being harnessed to craft advertising that is engaging and even tailored to personal interests and preferences, yet potentially distracting and irritating.This research seeks to evaluate contemporary digital advertising methods by assessing how a
Mammalian hibernators undergo substantial changes in metabolic function throughout the seasonal hibernation cycle.We report here the polar metabolomic profile of white adipose tissue Floor - Nets isolated from active and hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus).Polar compounds in white adipose tissue were extracted f
Marine sediments from the western coast of southern Africa record the origin of the Benguela Upwelling System, one of the most productive in the world.High productivity, in turn, is reflected in a diverse marine mammal fossil assemblage, comprising whales, dolphins and a phocid seal.Here, we describe new records of baleen whale (mysticete) fossils
Abstract Proteasome dependency is a feature of many cancers that can be targeted by proteasome inhibitors.For some cancer types, notably breast Headband cancer and triple-negative breast cancer (TNBC), high mRNA expression of a modified form of the proteasome, called the immunoproteasome (ImP), correlates with better outcomes and higher expression
Pulmonary artery hypertension (PAH) is a progressive chronic disease with a high mortality rate.Increased pulmonary vascular resistance and over-proliferation of Cup Set pulmonary artery endothelial cells lead to remodeling of pulmonary vasculature.Several anti-PAH therapies targeting various pathways involved in PAH progression have been approved